Table 2. Relationship between AFP mRNA/VEGF determinations and clinical-morphological characteristics of enrolled HCC patients.
AFP mRNA | VEGF | |
LR (P) | LR (P) | |
Age>62 years | 2–14 (0,1430) | 5,07 (0,0243) |
Sex Male | 1,28 (0,2578) | 0,13 (0,7211) |
Nodule size>3,5 cm | 2,60 (0,1069) | 7,62 (0,0058) |
Multinodular | 0,53 (0,4654) | 0,03 (0,8636) |
Gross vascular invasion | 12,91 (0,0003) | 15,21 (<0,0001) |
VEGF>23 pg ml−1 | 18,55 (<0,0001) | — |
AFP mRNA positive | — | 18,55 (<0,0001) |
AFP>29 ng l−1 | 6,97 (0,0083) | 7,27 (0,0070) |
CRPH | 0,13 (0,7182) | 5,41 (0,0200) |
Bilobar | 2,94 (0,0865) | 1,29 (0,2565) |
Surgery | 0,19 (0,6619) | 0,07 (0,7898) |
Albumin<36 g l−1 | 0,31 (0,5783) | 0,09 (0,7635) |
PT<70% | 5,23 (0,0215) | 2,40 (0,1209) |
Bilirubin>21 µmol l−1 | 4,20 (0,0404) | 2,99 (0,0839) |
Creatinine>84 µmol l−1 | 0,16 (0,6869) | 0,68 (0,4097) |
AST>76 U/l | 0,65 (0,4201) | 0,04 (0,8356) |
ALT>59 U/l | 1,11 (0,2917)) | 1,72 (0,1891 |
ALP>123 U/l | 1,70 (0,1927) | 0,06 (0,8011) |
GGT>68 U/l | 3,29 (0,0695) | 0,09 (0,7635) |
Child- Pugh B–C | 0,02 (0,8826) | 0,02 (0,8940) |
TNM | 18,34 (0,0001) | 22,09 (<0,0001) |
BCLC | 13,35 (0,0013) | 21,23 (<0,0001) |
PST>1 | 8,63 (0,0033) | 6,51 (0,0107) |
Grading | 58,35 (<0,0001) | 13,04 (0,0015) |
HCV+ | 4,20 (0,0458) | 3,04 (0,0812) |
LR, likelihood ratio test.