Table 4. Evaluation of the independent contribution of each variable to Cox Proportional Hazard Model. Multivariate Survival Analysis using AFP mRNA and VEGF as an integrated variable.

Variable	Hazard Ratio
	(95% CI)	p Value
Nodule size>3,5 cm	1,24 (0,87–1,78)	0,2389
Multinodular	1,28 (0,92–1,82)	0,1481
Macroscopic vascular invasion	0,35 (0,12–1,01)	0,0517
Grading
Moderately versus well differentiated	1,76 (0,84–3,81)	0,1049
Poorly versus moderately differentiated	1,54 (0,74–3,25)
AFP mRNA/VEGF (3 stages)
− + or +− versus − −	2,36 (1,14–4,99)	0,0305
+ + versus − + or + −	1,12 (0,52–2,41)
Bilobar	0,72 (0,36–1,40)	0,3360
Child- Pugh B–C	1,26 (0,93–1,74)	0,1379
Surgery	1,66 (1,22–2,30)	0,0011
PST>1	1,33 (0,64–2,72)	0,4351
TNM
III versus I–II	1,58 (0,60–4,07)	0,6306
IV versus III	0,89 (0,38–2,15)
BCLC
B versus A	0,74 (0,29–1,91)	0,0055
C–D versus B	6,30 (2,08–18,53)

AFP mRNA/VEGF (3 stages): stage 1 = − −, stage 2 = − + or + −, stage 3 = + +.

AFP mRNA/VEGF (4 stages): stage 1 = − −, stage 2 = − +, stage 3 = + −, stage 4 = + +.