Table 3. Pathway analysis of gene expression in morphologically normal prostate tissue in men who took lycopene supplements for three months (n = 29) compared with placebo (n = 28).
| Ingenuity Canonical Pathways | p-value |
| Nrf2-mediated Oxidative Stress Response | 0.0014 |
| Apoptosis Signaling | 0.0072 |
| Ceramide Signaling | 0.0089 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 0.0098 |
| Glutamate Metabolism | 0.0178 |
| Axonal Guidance Signaling | 0.0380 |
| Glutathione Metabolism | 0.0389 |
| PXR/RXR Activation | 0.0479 |