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. 2011 Sep 1;6(9):e24029. doi: 10.1371/journal.pone.0024029

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Collier et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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All components of MT1-MMP cell surface collagenolytic complex are shown to be mobile on the collagen fibril. Activated MT1-MMP can initiate the digestion of collagen fibril and is a Brownian Ratchet capable of biased diffusion similar to the secreted collagenase MMP-1. MMP-2/TIMP-2 complex is capable of random lateral diffusion on the same substrate and can assist in MT1-MMP dependent degradation of the fibril to small peptides. Integrin, a collagen receptor, can bind to collagen fibril and potentially interact with the MT1-MMP complex. The exact mechanism of that interaction remains to be elucidated. The arrow indicates hypothetical directionality of transport.