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. 2011 Sep 1;7(9):e1002235. doi: 10.1371/journal.pgen.1002235

Figure 5. Mammalian HCF-1 and HCF-2 regulate the expression of FOXO target genes.

Figure 5

(A) INS-1 cells treated with HCF-1 or control siRNA. (B) INS-1 cells treated with HCF-2 or control siRNA. mRNA levels of Bim, Gadd45a, p27,and IGFBP1 were quantified using RT-qPCR and normalized to the level of β-actin. The mean normalized RNA level for each gene in sicontrol treated cells was set to 1. The data represented are pooled from three independent experiments and are represented as mean +/− SEM. * denotes a p-value<0.05 relative to sicontrol.