Table 3. Summary of the non-parametric linkage results for diabetic nephropathy on the regions showing significant or suggestive evidence of linkage.

				Non-parametric two-point		Non-parametric multipoint
	Chr	cM	Markera	ASP LOD	All-ASP LOD	NPLpair LOD	NPLqtl LOD
Finnish	5p15	36.73	D5S416	0.13	0.95	0.18	1.94
	5p14	46.2	D5S419	0.07	1.20	0.20	2.06
	6p21	47.9	D6S276	2.31	0.43	2.10	0.24
	15q15.1	42.62	D15S994	0.08	1.28	0.42	1.74
	16p12	49.5	D16S3068	1.82	0.28	2.09	0.28
	17q25.3	129.62	D17S784	0.22	2.04	0.34	1.35
	22q11	2.96	D22S420	2.09	0.07	1.30	0.32
Danish	22q11	2.96	D22S420	0.66	0.59	1.35	1.15
French	6p23	34.61	D6S289	1.36	2.61	1.18	1.20
	9p21.2	51.5	D9S161	0.83	1.94	1.15	2.19
	22q11	2.96	D22S420	0.33	0.00	0.97	0.01
Joint	6p23–p22.3	34.61	D6S289	1.79	2.41	1.95	1.49
	6p22.3	42.83	D6S422	1.06	0.27	2.04	0.27
	6p21	47.93	D6S276	2.82	0.37	2.35	0.04
	7q21.11	162.09	D7S669	0.14	1.92	0.23	0.75
	22q11	2.96	D22S420	2.78	0.31	3.58	0.86
Joint including finemapping markers	22q11	2.96	D22S420	2.78	0.31	2.19	0.60
	22q11.21	5.8	D22S427a	0.51	0.12	1.69	0.82
	22q11.21–q22	14.68	D22S539	0.47	0.82	1.43	1.49
	22q11.23	18.8	D22S1174a	1.49	1.13	1.28	1.20
	22q11.23–q12.1	22.59	D22S315	0.07	0.6	0.86	1.37
	22q12.1	24.38	D22S1154a	0.15	0.64	1.09	1.33
	22q12.1	30.54	D22S1163a	0.71	0.74	0.84	0.52

Chr = chromosome; cM = centiMorgan; ASP = two-point affected sib-pair LOD score; NPL = multi-point non-parametric LOD score based on Merlin sib-pair analysis; NPL_{qt l} = multi-point non-parametric LOD score based on Merlin qtl-analysis;

^aadditional markers genotyped on chromosome 22q.

Results on D22S420 are shown in each population and results after mapping four additional markers on chromosome 22q11–q12 in the joint sample set.