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. 2011 Sep 1;7(9):e1002127. doi: 10.1371/journal.pcbi.1002127

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Reuveni et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The figure depicts ten typical profiles of translation rate vs. the initiation rate (blue) in S. cerevisiae genes; the mean genomic profile is shown in red. As can be seen, for very small values all genes have similar translation rate (mainly determined by λ and not by the codon-bias), whereas for larger λ translation rates differ among genes and asymptotically converge to the elongation rate capacity. B. The predicted translation rate for highly (top 25%, Blue line) and lowly (lowest 25%, Red line) expressed genes.

Inline graphic — A. The figure depicts ten typical profiles of translation rate vs. the initiation rate (blue) in S. cerevisiae genes; the mean genomic profile is shown in red. As can be seen, for very small values all genes have similar translation rate (mainly determined by λ and not by the codon-bias), whereas for larger λ translation rates differ among genes and asymptotically converge to the elongation rate capacity. B. The predicted translation rate for highly (top 25%, Blue line) and lowly (lowest 25%, Red line) expressed genes.