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. 2011 Sep 1;6(9):e24142. doi: 10.1371/journal.pone.0024142

Figure 3. Sotrastaurin does not affect cell-to-cell spread of HCV.

Figure 3

(A) HCV-positive donor cells were mixed with HCV-negative target cells under an agarose overlay preventing cell-free virus spread in the presence or absence of sotrastaurin. Target cells contained a tagRFP-reporter that assumes a cytosolic or nuclear localization depending whether the cells are uninfected or infected with HCV. After 96 hours of co-culture nuclei were co-stained with DAPI. (B) Percentage of infected target cells after 96 hours of co-culture.