Table 3. Comparison between results of Urovysion FISH (in two selected tumoral areas of the same FFPE section) and array-CGH.
| SAMPLE | UROVYSION AREA 1 | UROVYSION AREA 2 | Array-CGH | ||||
| LOSS% | GAIN% | LOSS% | GAIN% | LOSS% | GAIN% | ||
| 075CR09 LG NI | CR3* | 12 | 29 | na | na | - | - |
| CR7** | 2 | 24 | na | na | - | - | |
| CR17* | 25 | 12 | na | na | - | - | |
| 9p21** | 46 | 5 | na | na | mosaic 48% | - | |
| 080CR09 LG NI | CR3** | 4 | 27 | 4 | 16 | - | 3q25.2, 1.2 Mb, amplification 3q26.1, 1.8 Mb, non mosaic |
| CR7 | 7 | 8 | 4 | 12 | - | - | |
| CR17** | 25 | 3 | 10 | 8 | 17p13.3, 0.07 Mb, mosaic 87% | - | |
| 9p21 | 100 | 0 | 100 | 0 | non mosaic | - | |
| 082CR09 LG NI | CR3* | 1 | 29 | na | na | - | - |
| CR7** | 0 | 14 | na | na | - | - | |
| CR17** | 7 | 7 | na | na | - | - | |
| 9p21* | 93 | 1 | na | na | - | - | |
| 028CR09 HG NI | CR3 | 1 | 56 | 0 | 53 | - | 3p25.2-p25.1, 2 Mb, amplification 3p21.31, 3 Mb, mosaic 62% 3q11.2-q29, 99.5 Mb, mosaic 51% |
| CR7 | 3 | 57 | 0 | 33 | 7p22.3, 0.1 Mb, non mosaic | 7p22.2-p22.1, 2 Mb, mosaic 80% 7p15.3, 0.3 Mb, mosaic 62% 7p14.2, 0.28 Mb, non mosaic 7q11.21-q11.23, 1.2 Mb, mos 77% 7q21.3-q22.2, 7.6 Mb, mosaic 62% 7q32.1-q32.2, 1 Mb, mosaic 85% 7q33.34, 2.9 Mb, mosaic 77% 7q36.1, 0.7 Mb, non mosaic | |
| CR17 | 0 | 53 | 1 | 39 | - | 17q11.1-q25.3, 56 Mb, mosaic 85% | |
| 9p21 | 55 | 4 | 78 | 1 | non mosaic | - | |
| 004CR10 HG IN | CR3** | 20 | 18 | 14 | 28 | - | 3q25.32-q26.1, 2.2 Mb, mos 51% |
| CR7* | 8 | 12 | 4 | 24 | - | 7p21.1, 3.6 Mb, mos 68% | |
| CR17* | 28 | 4 | 18 | 21 | - | 17p11.2, 0.4 Mb, mosaic 48% 17q11.2, 2.9 Mb, mosaic 45% 17q12-q25.3, 49 Mb, mosaic 39% | |
| 9p21** | 70 | 0 | 28 | 13 | - | - | |
| 009CR10 HG IN | CR3 | 0 | 52 | 0 | 38 | - | 3p26.3-p11.1, 90 Mb, mosaic 75% 3q11.2-q29, 104.2 Mb, mosaic 60% |
| CR7 | 0 | 56 | 0 | 44 | - | 7p22.3-p11.2, 56.2 Mb, mosaic 39% 7q11.21-q36.3, 96.3 Mb, mosaic 66% | |
| CR17 | 0 | 49 | 0 | 38 | 17p13.3-p11.2, 21.8 Mb, mosaic 33% | 17q11.1-q25.3, 55.8 Mb, mosaic 28% | |
| 9p21 | 76 | 1 | 96 | 0 | mosaic 33% | - | |
| 010CR10 HG IN | CR3 | 3 | 31 | 2 | 49 | 3p21.31-p12.1, 35.1 Mb, mosaic 28% | 3p16.3-p24.3, 6.6 Mb, mosaic 68% |
| CR7** | 0 | 33 | 1 | 31 | 7p21.1, 0.3 Mb, mosaic 91% | - | |
| CR17 | 10 | 25 | 9 | 25 | - | 17q11.1-q25.3, 55.7 Mb, mosaic 30% | |
| 9p21 | 91 | 1 | 99 | 0 | non mosaic | - | |
| 026CR10 HG IN | CR3** | 0 | 38 | 0 | 39 | 3p21.31-p21.1, 4.2 Mb, mosaic 27% | - |
| CR7* | 1 | 15 | 0 | 34 | - | - | |
| CR17* | 7 | 19 | 0 | 25 | - | - | |
| 9p21 | 32 | 30 | 97 | 0 | mosaic 68% | - | |
| 070CR09 HG IN | CR3 | 0 | 52 | 0 | 38 | - | 3p25.2-p25.1, 0.7 Mb, amplification |
| CR7 | 0 | 44 | 0 | 58 | - | 7p22.3-q36.3, 158 Mb, mosaic 66% | |
| CR17 | 10 | 50 | 6 | 44 | 17q11.2-q12, 1 Mb, mosaic 48% | 17q21.31-q25.3, 40 Mb, mosaic 46% | |
| 9p21** | 18 | 32 | 4 | 46 | - | - | |
| 081CR09 HG IN | CR3 | 0 | 58 | 0 | 41 | - | 3p25.2, 0.06 Mb, mosaic 62% |
| CR7** | 0 | 52 | 2 | 25 | - | - | |
| CR17** | 1 | 47 | 12 | 25 | - | - | |
| 9p21** | 11 | 42 | 13 | 33 | - | - | |
LOSS: number of signals: 0 and 1; DISOMY: number of signals even (2, 4, 6, 8, 10, 12); GAIN number of signals odd (3, 5, 7, 9, 11).
Gray: CNA detected by both techniques and by both tumoral FISH areas.
**: CNA detected by both techniques but by only one tumoral FISH area; or by both tumoral FISH area but not by array-CGH.
*: CNA detected by only array-CGH, or by only one tumoral FISH area.
Positive FISH if at least 25% of cells detected the CNA.
Na: not available.