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. 2011 Sep 1;6(9):e24216. doi: 10.1371/journal.pone.0024216

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Hollestelle et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative example of GrM in plasma of patients with meningococcal disease without shock (1) and with shock (2–5), using immunoblotting with a monoclonal antibody against GrM. (B) VWF and FVIII levels in plasma were determined by ELISA and chromogenic activity, respectively. VWF/FVIII ratios were determined in meningococcal shock patients with or without detectable plasma GrM, patients with meningococcal disease without shock, and healthy controls. P values are indicated. (C) VWF/FVIII ratios are plotted against plasma GrM levels, as quantified by western blot. R_spearman = 0.92, p<0.001.