Figure 1. Important genes in colorectal cancer development.

A) Key genes targeted in the various CRC phenotypes during development from precursor lesions to carcinomas. Genes in bold represent MAPK, PI3K, and TP53 signaling networks, and their mutation status have previously been determined [38]. B) The figure shows how part of the phosphatidyl inositol network interacts with the canonical PI3K pathway. Genes of which mutation status data are used for association analyses in the current paper are colored in blue, pink and brown. Abbreviations: GPCR, G-protein coupled receptor; RTK, receptor tyrosine kinase.