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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Future Med Chem. 2011 Aug;3(10):1289–1306. doi: 10.4155/fmc.11.77

Figure 5. The putative parasite pocket (P-pocket).

Figure 5

(A) Superposition of the M-loop region of LmjPDEB1 (green) and of human PDE4D (blue). The positioning of Rolipram is taken from the co-crystal of human PDE4D with rolipram. (B) Surface presentation of the parasite pocket (P-pocket) in LmjPDEB1. (C) The sequence alignment of the pocket among trypanosome, Leishmania and human PDEs. The red color marks the identical amino acids in all phosphodiesterases. Two blue residues (Met-874 and Gly-886 in LmjPDEB1) play a gatekeeper role to isolate the parasite pocket from the active sites of human phosphodiesterase families [71].