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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Hepatology. 2010 Feb;51(2):621–632. doi: 10.1002/hep.23365

Figure 4. TLR9 is necessary for neutrophil-mediated I/R injury.

Figure 4

Neutrophil (CD11bhiLy6G+) recruitment to the ischemic liver after 12 h of I/R or sham surgery is represented as (A) percentage of hepatic CD45+ leukocytes or (B) absolute number of neutrophils. WT or TLR9−/− mice were depleted of neutrophils and (C) serum ALT and (D) serum cytokines were determined 12 h after I/R. Data in (B–D) represent means ± SEM and in (A–D) are representative of at least 2 independent experiments (4–6 mice/group). *p<0.05; **p<0.01; ***p<0.001.