Figure 5. CDRα sequences that contain other amino acids that frequently bind MHC at the same position.

Listed are the human and mouse V region CDR1α sequences that include a Y at position 29 (a), or the human and mouse V region CDR2α sequences that contain a Y at position 50 (b). The amino acid of interest is in each case boxed in red. The sequences were selected and numbered as in Figure 3a and structures were selected from those in Figure 2.