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. 2011 Aug 17;31(33):11748–11755. doi: 10.1523/JNEUROSCI.1887-11.2011

Figure 3.

Figure 3.

Aromatase inhibition dramatically dysmasculinizes the neonatal brain miRNA environment during the perinatal sensitive period. Administration of a single injection of the aromatase inhibitor, formestane (20 μg), on PN1 produced a profound effect on the brain miRNA environment as analyzed by miRNA Taqman qRT-PCR Array. Pearson Correlational Hierarchical Clustering analysis of miRNA expression patterns was unable to distinguish between control female and formestane-treated males, while completely segregating control male samples from these groups, supporting a novel role of miRNA in organizing the sexually dimorphic brain. All data are mean per group ± SEM, n = 7–8 litters/group.