Overall models with CoMSIA molecular descriptor surfaces for both rigid and flexible structure alignments of compounds active against L. amazonensis; DB766 is displayed as a reference compound. Favored potentials from steric to H-acceptor molecular descriptors are green, blue, yellow, cyan, and magenta, whereas disfavored potentials from steric to H-acceptor molecular descriptors are yellow, red, gray, purple, and red. Results for L. donovani can be found in Supplemental Figure S1.