Table 3.
Cell growth inhibition (IC50, nM) with spongistatin 1 and the synthesized analogs
| MDA-MB-435 | HT-29 | H522-T1 | U937 | |
|---|---|---|---|---|
| (+)-Spongistatin 1 | 0.0225 | 0.058 | 0.16 | 0.059 |
| (−)-38 | 82.8 | 161.2 | 297.2 | 60.5 |
| 17 | >1000 | >1000 | >1000 | >1000 |
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