Table 1.
Summary of Results
| Entry | Structure | Name | IC50a | ΔTm | Resolution |
|---|---|---|---|---|---|
| 8 |
|
7-carboxy pterin (7CP) | 230 μM | 2°C | 1.29 Å |
| 4 |
|
7-carbamoyl pterin (7AP) | No Inhibition | 1°C | 1.75 Å |
| 9 |
|
N-methyl-7-carbamoyl pterin | 1.6 mM | 0.4 °C | 1.26 Å |
| 10 |
|
N-(methylamino pyridinyl)-7-carbamoyl pterin | 500 μM | 1°C | 1.26 Å |
| 11 |
|
N-(3,4,5-trimethoxy benzyl)-7-carbamoyl pterin | No Inhibition | 1°C | NA |
| 12 |
|
N-(furanylmethyl)-7-carbamoyl pterin | 380 μM | 2°C | 1.89 Å |
| 13 |
|
N-(4-fluorobenzyl)-7-carbamoyl pterin | 570 μM | 2°C | NA |
| 14 |
|
N-(2-(phenylamino) ethyl)-7-carbamoyl pterin | 210 μM | 3°C | 1.75 Å |
| 15 |
|
7-hydrazide pterin (7HP) | 500 μM (35%) | <1σ | 1.97 Å |
| 5 |
|
7-propionyl pterin | 700 μM | 2°C | 1.35 Å |
| 6 |
|
7-acetyl pterin | 500 μM (20%) | 1.3°C | 1.26 Å |
| 7 |
|
7-(p-methoxy benzoyl) pterin | No Inhibition | <1σ | NA |
a
= When 50% inhibition was not reached.
% inhibition given in parenthesis at maximum concentration