Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Med Chem. 2011 Jun 23;46(9):4178–4183. doi: 10.1016/j.ejmech.2011.06.020

Table 3.

Anti-HIV activity of compound 11 against NIH reagent program NRTI-resistant virus panel.

NRTI Resistant Virus Panel EC50 (nM) a
7324-1 (M41L, D67N, K70R, T215F, K219E, T69N) 0.595
7324-4 (M41L, K70R, T215F, K219E) 0.735
10076-4 (M41L, T215Y, M184V) >40,000 b
7295-1 (D67N, K70R, T215F, K219Q, M184V, T69N) >40,000
4755-5 (M41L, D67N, L210W, T215Y, M184V, T69D, E44D, V118I) >40,000
6463-13 (M41L, D67N, L210W, T215Y, M184V, V118I) >40,000
7303-3 (M41L, D67N, L210W, T215Y, T69D, E44D, V118I) 0.56
1617-1 (K70G, M184V, T69K, V75I, F77L, F116Y, Q151M) 32.2
35764-2 (V75I, F77L, F116Y, Q151M) 0.42
29129-2 (M41L, D67N, L210W, T215Y, M184V) >40,000
56252-1 (K70R, V75I, F77L, F116Y, Q151M, K65R) 0.525
NL4-3 (wild-type) 0.318
a

EC50 (nM) is the concentration that inhibits HIV by 50%. Results were averaged from at least two separate experiments.

b

The highest concentration tested was 40,000 nM.