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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Psychoneuroendocrinology. 2011 May 26;37(1):27–38. doi: 10.1016/j.psyneuen.2011.04.014

Figure 6. HPA Axis Reactivity following CeA CRF-OE (Experiment-2) is similar to that in control subjects.

Figure 6

In the DST, two-factor ANOVA identified a significant main effect of dexamethasone injection on plasma corticosterone (A) and ACTH (B). Post-hoc Bonferroni tests demonstrated that within the LVCMVGFP group, both plasma corticosterone and ACTH concentrations were significantly decreased. Notably, in rats overexpressing CeA CRF, dexamethasone administration failed to significantly suppress corticosterone. ACTH concentration was significantly suppressed by dexamethasone. In the CRF-Stimulation Test, two-factor ANOVA identified a significant effect of CRF injection, but not of virus, on plasma corticosterone (C) and ACTH (D) concentrations. Post-hoc Bonferroni analysis revealed that within the LVCMVGFP group, exogenous administration of CRF significantly increased plasma corticosterone concentration but not ACTH concentration. In rats chronically overexpressing CeA CRF, exogenous CRF administration stimulated corticosterone and ACTH concentrations. The Dex/CRF Test revealed no significant differences in plasma corticosterone (E) or ACTH (F) concentration between the LVCMVGFP and LCRFp3.0CRF groups in either the Sal/Sal condition or in the more sensitive Dex/CRF test. (* = significant difference from LVCMVGFP Sal/Sal; p < 0.05; ** p < 0.01 † = significant difference from LVCRFp3.0CRF Sal/Sal; p < 0.05; ††, p < 0.01; ††† p < 0.001)