Table 3.
Lung function and markers of inflammation in asthmatic participants pre- and 12 months post bariatric surgery*
| Visit 0 | Visit 12 | p | |
|---|---|---|---|
| PC20 (mg/ml methacholine)† | 3.90 ± 3.59 | 7.28 ± 6.50 | 0.03 |
| FEV1 (% predicted) | 82.4 ± 14.1 | 90.4 ± 14.2 | < 0.01 |
| FVC (% predicted) | 84.1 ± 12.9 | 93.9 ± 15.5 | < 0.001 |
| FEV/FVC (% predicted) | 98.8 ± 14.3 | 96.8 ± 8.2 | 0.74 |
| BAL macrophages (%)‡ | 93.0 ± 4.1 | 90.3 ± 6.0 | 0.13 |
| BAL lymphocytes (%)‡ | 3.5 ± 2.6 | 7.9 ± 5.7 | < 0.01 |
| BAL neutrophils (%)‡ | 3.1 ± 3.4 | 1.6 ± 1.5 | 0.18 |
| BAL eosinophils (%)‡ | 0.51 ± 0.75 | 0.23 ± 0.61 | 0.27 |
| BAL leptin (pg/ml)‡ | 35.3 ± 65.4 | 29.4 ± 30.0 | 0.63 |
| BAL adiponectin (pg/ml)‡ | 1527 ± 1313 | 4530 ± 6168 | 0.01 |
| Serum IgE (IU/ml) | 133.3 ± 172.2 | 133.9 ± 150.1 | 0.95 |
| Serum leptin (ng/ml) | 30.2 ± 30.5 | 17.1 ± 13.4 | 0.096 |
| Serum adiponectin (μg/ml) | 13.8 ± 10.5 | 25.2 ± 16.3 | 0.003 |
*
Values shown are mean plus-minus standard deviation. FEV1, FVC and FEV1/FVC are % predicted from Hankinson 48 BAL is bronchoalveolar lavage. p values are shown repeated measures analysis of variance comparing controls and asthmatics before and 12 months after bariatric surgery. For BAL eosinophils, p value is shown for Kruskal Wallis test.
†
n=17 at visit 0 and 12
‡
n=21 at visit 0, n = 17 at visit 12.