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. 2011 Jul 30;5(4):315–323. doi: 10.1016/j.molonc.2011.07.007

Figure 1.

Figure 1

Schematic representation of the steps leading to, or avoiding, aneuploidy. Wild type p53 function is crucial for the elimination of tetraploid cells from the replicating pool. Loss of p53 and p73 tumor suppressors facilitates aneuploid tumor formation. Orange boxes represent proliferation “stops”, whereas green represents proliferation “go”.