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Systemic administration of JWH133 (10, 20 mg/kg, i.p., 30 min prior to cocaine) dose-dependently inhibited cocaine-enhanced locomotion in WT (a, two-way ANOVA for repeated measures over time, F2,16 = 14.45, P < 0.001) and CB1−/− (b, F2,18=12.57, p<0.001), but not in CB2−/− (c, F2,12 = 0.17, P = 0.85), mice. Data are means ± s.e.m. ** P < 0.01, *** P < 0.001, compared to vehicle treatment group.
