. Author manuscript; available in PMC: 2011 Sep 2.

Published in final edited form as: J Allergy Clin Immunol. 2011 Apr 13;128(2):418–420. doi: 10.1016/j.jaci.2011.03.007

TABLE I.

Logistic regression analyses of associations of genotype or genotype combinations and exposure (HDI vs. MDI and/or TDI) with OA confirmed by specific inhalation challenge (DA+) versus specific inhalation challenge negative (DA−) workers in all diisocyanate exposed workers (Part A), and of genotype or genotype combinations with OA in HDI exposed workers (Part B), after adjusting for significant demographic characteristics.

Genotype or genotype combinations of IL4RA (I50V), IL13 (R110Q), and CD14 (C159T) SNPs.	P-values			OR (95% CI) for genotype among diisocyanate exposed workers
	Genotype or genotype combination main effect	Exposure main effect, HDI vs. MDI, TDI	Genotype or genotype combination by exposure interaction	OR (95% CI) for genotype among diisocyanate exposed workers
A. All workers
IL4RA II	0.810	0.0001	0.100	1.57 (0.74, 3.32)^a
IL4RA II and IL13 RR	0.578	0.005	0.051	1.66 (0.66, 4.17)^a
IL4RA II and CD14 CT	0.895	0.033	0.006	2.98 (1.25, 7.09)^a
IL4RA II and IL13RR and CD14 CT	0.801	0.564	0.003	3.55 (1.19, 10.55)^b
B. HDI workers only
IL4RA II	0.292			1.51 (0.70, 3.28)^a
IL4RA II and IL13 RR	0.340			1.58 (0.62, 4.06)^a
IL4RA II and CD14 CT	0.015			3.08 (1.25, 7.60)^a
IL4RA II and IL13RR and CD14 CT	0.019			3.86 (1.26, 11.98)^c

Note that genotypes are dichotomized so that IL4RA II compares the II genotype to the IV or VV genotypes; IL13 RR compares the RR genotype to the RQ or QQ genotypes; CD14 CT compares the CT genotype to the CC or TT genotype. Combinations of genotypes compare the indicated SNP combination to all other combinations. For example, IL4RA II and IL13 RR compares the combination of IL4RA (I50V) = II and IL-13 (R110Q) = RR to all other combinations of IL4RA (I50V) and IL-13 (R110Q).

Adjusted for smoking

Adjusted for smoking and ethnicity

Adjusted for smoking and gender