Figure 1. The mTOR signaling pathway.
4E-BP: 4E-binding protein; Akt: Protein kinase B; eIF4E: Elongation initiation factor 4E; IRS: Insulin receptor substrate; mTOR: Mammalian target of rapamycin; PI3-K: Phosphatidylinositol 3-kinase; Raptor: Regulatory associated protein of TOR; Rheb: Ras homolog enriched in brain; Rictor: Rapamycin insensitive companion of TOR; S6K: P70 S6 kinase; TSC: Tuberous sclerosis complex.
Reproduced with permission from [38].