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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Therapy. 2011 Jul;8(4):359–367. doi: 10.2217/thy.11.32

Figure 1. The mTOR signaling pathway.

Figure 1

4E-BP: 4E-binding protein; Akt: Protein kinase B; eIF4E: Elongation initiation factor 4E; IRS: Insulin receptor substrate; mTOR: Mammalian target of rapamycin; PI3-K: Phosphatidylinositol 3-kinase; Raptor: Regulatory associated protein of TOR; Rheb: Ras homolog enriched in brain; Rictor: Rapamycin insensitive companion of TOR; S6K: P70 S6 kinase; TSC: Tuberous sclerosis complex.

Reproduced with permission from [38].