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. Author manuscript; available in PMC: 2012 Aug 30.
Published in final edited form as: Biochemistry. 2011 Aug 5;50(34):7405–7413. doi: 10.1021/bi200506k

Figure 1.

Figure 1

Representation of the human thin filament containing human cTn, Tm and actin: yellow=cTnT; blue=cTnI; red=cTnC; cyan=calcium ion; green/orange=overlapping Tm; silver/gray=actin filament (The same color scheme is used in the provided movies, except calcium ions in the movie are colored black vice cyan). This figure was obtained by orienting the cTn and Tm to an actin backbone, docking cTnT to overlapping Tm, and performing a 50 ps simulation in equilibrium at 70 K using CHARMM version 33b1(23) of cTn and the overlapping Tm without actin. The resulting cTn-Tm complex is shown here in duplicate with actin added.