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Alignment of Ca2+-saturated and Ca2+-depleted average structures of cTnI. The N-terminus and switch peptide and surrounding regions of the C-terminus interact with the N-lobe of cTnC and are altered as a function of Ca2+-binding. As a result, fluctuations in the dynamics of the N-lobe cTnC alter the dynamics of switch peptide of the C-terminus cTnI and the N-terminus of cTnI. id=inhibitory domain; sp=switch peptide.
