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. Author manuscript; available in PMC: 2011 Sep 2.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Mar 30;20(10):3112–3115. doi: 10.1016/j.bmcl.2010.03.093

Scheme 1.

Scheme 1

Reagents and conditions: (a) MeMgI or EtMgBr, Et2O, 30 °C; (b) PCC, CH2Cl2, rt, 83% (for 4, two steps) and 86% (for 5, two steps); (c) DIBAL-H, CH2Cl2, −68 °C; (d) Al2O3, 250 °C, 62% (for 6, two steps) and 65% (for 7, two steps).