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. Author manuscript; available in PMC: 2012 Sep 28.
Published in final edited form as: Tetrahedron Lett. 2011 Sep 28;52(39):5070–5072. doi: 10.1016/j.tetlet.2011.07.094

Scheme 1.

Scheme 1

Preparation of FKBD from rapamycin. (a) TBSOTf, Et3N, CH2Cl2, r.t., 100%; (b) O3, CH2Cl2, −68 °C; then 35% H2O2, r.t.; (c) CH3PPh3Br, t-BuOK, THF, 0 °C (54% b–c); (d) CF3COOH, H2O, 0 °C (96%).