Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
HPLC chromatograms of products formed upon incubation of yeast microsomes containing CYP17A1 or CYP21A2 and mutations with P4. The top panel shows absorbance at 254 nm from standards (Stds) of P4, 17OHP4, 11-deoxycorticosterone (DOC), androstenedione (AD), and 16OHP4. Lower four panels show radioactivity derived from P4 metabolism by CYP17A1, wild-type CYP21A2, CYP21A2 mutation V359A, and CYP21A2 mutation V359G. Small arrows atop each panel track elution positions of standards.
