Table 5.

Controlled drug administration studies with oral fluid collection.

THC (cannabinoids)	Opioids	Amphetamines	Cocaine	BENZOa	Doses	Study participants, N	Reference
x					1 Cannabis joint, potency unknown	3	Jehanli et al. (125)
x					20–25 mg Smoked THC 20–25 mg THC (brownies)	15 3	Niedbala et al. (44)
x					0, 1.75, and 3.55% Smoked THC	6	Huestis and Cone (13)
x					Passive cannabis smoke exposure	4	Niedbala et al. (38)
x					Passive cannabis smoke exposure	4	Niedbala et al. (39)
x					0, 250, and 500 μg/kg Smoked THC	10	Ramaekers et al. (36); Kauert et al. (37)
x					1 Cannabis joint, potency unknown	1	Moore et al. (40)
	x				30 mg Oral codeine	3	Sharp et al. (126)
	x				60 and 120 mg Intramuscular codeine	1	Cone (127)
	x				Oral codeine	8	Chen et al. (128)
	x				30 mg Oral liquid codeine phosphate	17	O’Neal et al. (129)
	x				30 mg Oral liquid codeine phosphate	37	O’Neal et al. (130)
	x				16 mg Oral codeine	5	Jehanli et al. (125)
	x				Single and multiple 60 and 120 mg/70 kg codeine	19	Kim et al. (48); Kacinko et al. (49)
	x				Poppy seed bagels and poppy seeds	7	Rohrig and Moore (50)
		x			10 or 20 mg MAMP	8	Schepers et al. (51)
		x			0, 75, and 100 mg Oral MDMA	18	Laloup et al. (53); Wood et al. (54)
		x			Single and multiple 10 and 20 mg MAMP	8	Huestis and Cone (52)
		x			75 mg MDMA	12	Peters et al. (55)
			x		25 mg Smoked, 32 mg intravenous, 42 mg insufflated cocaine, multiple oral cocaine up to 2000 mg/day	66	Jufer et al. (59)
				x	1 mg Oral flunitrazepam	4	Samyn et al. (61)
				x	50 mg Oral TZP or 10 mg oral DZP or repeated 25 mg oral TZP	7	Laloup et al. (62)
				x	15 and 30 mg Oxazepam	8	Smink et al. (63)

^aBENZO, benzodiazepines; MAMP, methamphetamine; MDMA, 3,4-methylenedioxymethamphetamine; DZP, diazepam; TZP, tetrazepam.