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. Author manuscript; available in PMC: 2011 Sep 2.
Published in final edited form as: J Genet Genomics. 2009 Feb;36(2):63–73. doi: 10.1016/S1673-8527(08)60093-4

Fig. 5.

Fig. 5

Protein folding funnel landscape. It is a downhill run. A folding protein can follow many paths to its most energetically stable native (N) conformation (from Dill and Chan, 1997). More than ten orders of scale in energy have been involved, showing that such an idea can be used to link various hierarchical levels. The dynamical flow is somehow opposite to that in Waddington's developmental landscape.