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. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Anal Chem. 2011 Aug 1;83(17):6683–6688. doi: 10.1021/ac201224n

IC₅₀ values determined for COX-2 inhibitors using the high throughput assay. (A) COX-2 inhibitors indomethacin (■) and sulindac sulfide() were assessed against COX-2 metabolism of AA. IC₅₀ values determined were 110 nM and 290 nM, respectively. (B) Sterioisomers R-flurbiprofen (✱) and S- flurbiprofen (▲) were assessed against COX-2 metabolism of AA. IC₅₀ values determined were no inhibition and 120 nM, respectively.

Inline graphic — IC₅₀ values determined for COX-2 inhibitors using the high throughput assay. (A) COX-2 inhibitors indomethacin (■) and sulindac sulfide() were assessed against COX-2 metabolism of AA. IC₅₀ values determined were 110 nM and 290 nM, respectively. (B) Sterioisomers R-flurbiprofen (✱) and S- flurbiprofen (▲) were assessed against COX-2 metabolism of AA. IC₅₀ values determined were no inhibition and 120 nM, respectively.