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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Cancer Res. 2011 Jul 6;71(17):5707–5716. doi: 10.1158/0008-5472.CAN-11-0907

Figure 4.

Figure 4

Fetal liver chimeric (FLC) mice reveal that CXCR3 expression in the hematopoietic system promotes DMBA/TPA induced epidermal proliferation. (A) The indicated mice were generated with fetal liver transplantation of irradiated recipients and treated with short course DMBA/TPA (**p<0.01, n=3 for WT→WT, n=3 for WT→RAG2−/−, n=4 for WT→ CXCR3−/− and n=4 for CXCR3−/−→RAG2−/−, combined from 2 different experiments). BrdU incorporation was then determined and all mice (representative section in B of WT→CXCR3−/−) displayed WT levels of proliferation, except the CXCR3−/−→RAG2−/− (representative section in C).