Table II.
Genotype frequencies and relapse free survival*
| Gene | Genotype | Total N | Relapse N | RFS | 95% CI | HR* | 95% CI HR* | P value* |
|---|---|---|---|---|---|---|---|---|
| TS 28 bp insertion | 2R/2R | 83 | 15 | 0.80 | .691–.877 | 1 | reference | -- |
| 2R/3R | 196 | 38 | 0.79 | .726–.845 | 1.68 | 0.863–3.255 | 0.13 | |
| 3R/3R | 103 | 27 | 0.73 | .631–.806 | 1.87 | 0.942–3.721 | 0.074 | |
| 3R/4R | 20 | 7 | 0.60 | .342–.789 | 3.69 | 1.436–9.481 | 0.007 | |
| MTHFR C677T | C/C | 224 | 41 | 0.81 | .747–.854 | 1 | reference | -- |
| C/T | 187 | 46 | 0.74 | .667–.798 | 1.61 | 1.036–2.505 | 0.034 | |
| T/T | 72 | 20 | 0.70 | .578–.798 | 1.36 | 0.763–2.411 | 0.3 | |
| MTRR | A/A | 144 | 26 | 0.80 | .720–.860 | 1 | reference | -- |
| G/A | 225 | 62 | 0.72 | .650–.770 | 1.95 | 1.175–3.227 | 0.01 | |
| G/G | 128 | 23 | 0.81 | .724–.867 | 1.23 | 0.672–2.241 | 0.51 | |
| GSTP1*B | A/A | 147 | 26 | 0.81 | .738–.869 | 1 | reference | -- |
| G/A | 176 | 42 | 0.75 | .678–.809 | 1.47 | 0.889–2.442 | 0.13 | |
| G/G | 55 | 16 | 0.68 | .529–.789 | 1.94 | 1.010–3.732 | 0.047 | |
| TPMT (460 and 719) | Normal | 465 | 98 | 0.78 | .733–.812 | 1 | reference | |
| Heterozygote | 31 | 9 | 0.69 | .486–.828 | 1.86 | .932–3.725 | 0.078 | |
| Variant | 1 | 1 | -- | -- | -- | -- | -- | |
| GSTT1 | Present | 433 | 100 | 0.76 | .712–.794 | 1 | reference | -- |
| Null | 65 | 9 | 0.85 | .740–.922 | 0.54 | 0.271–1.078 | 0.081 |
*
Adjusted for age, gender, ethnicity, and day 7 bone marrow response