Table IV.
Average chemotherapy exposure by genotype
| Methotrexate | Prednisone | 6-MP | Vincristine | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | sd | Mean | sd | Mean | sd | Mean | sd | ||
| TS 28 bp insertion | 2R/2R | 74.4 | 18.6 | 97.5 | 3.5 | 76.3 | 15.4 | 96.4 | 8.0 |
| 2R/3R | 73.2 | 18.3 | 95.6 | 5.9 | 74.4 | 15.9 | 94.8 | 9.8 | |
| 3R/3R | 76.1 | 18.6 | 96.1 | 7.8 | 79.0 | 16.5 | 96.2 | 11.9 | |
| 3R/4R | 77.8 | 17.2 | 96.0 | 5.2 | 81.2 | 11.8 | 96.1 | 4.6 | |
| MTHFR C677T | C/C | 73.4 | 18.8 | 95.9 | 5.2 | 75.3 | 16.1 | 95.4 | 9.7 |
| C/T | 75.4 | 18.9 | 96.5 | 5.1 | 77.2 | 15.9 | 98.5 | 23.2 | |
| T/T | 71.8 | 20.0 | 95.1 | 8.7 | 74.1 | 16.5 | 93.4 | 15.3 | |
| MTRR | A/A | 76.1 | 18.7 | 96.3 | 5.6 | 76.6 | 17.0 | 96.7 | 7.3 |
| G/A | 73.7 | 18.8 | 95.2 | 7.8 | 75.6 | 15.4 | 96.5 | 22.5 | |
| G/G | 72.7 | 18.3 | 96.5 | 5.1 | 75.8 | 15.7 | 94.7 | 12.7 | |
| GSTP1*B | A/A | 73.2 | 17.3 | 95.8 | 7.3 | 76.5 | 14.1 | 96.0 | 7.9 |
| G/A | 74.2 | 18.7 | 95.5 | 7.2 | 74.8 | 16.0 | 96.5 | 25.7 | |
| G/G | 75.8 | 15.8 | 96.5 | 4.9 | 78.0 | 13.7 | 95.5 | 10.8 | |
| TPMT (416 and 719) | Normal | 73.9 | 18.2 | 96.1 | 6.8 | 75.9 | 15.6 | 96.5 | 18.7 |
| Heterozygote | 69.3 | 21.1 | 94.3 | 6.1 | 71.8 | 17.5 | 91.2 | 14.0 | |
| Variant | -- | -- | -- | -- | -- | -- | -- | -- | |
| GSTT1 | Present | 74.3 | 18.3 | 96.0 | 6.7 | 75.9 | 15.7 | 96.2 | 18.1 |
| Null | 71.9 | 21.5 | 95.8 | 5.7 | 75.9 | 16.5 | 96.3 | 5.4 | |