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. Author manuscript; available in PMC: 2012 Jun 8.
Published in final edited form as: Oncogene. 2011 May 30;30(49):4874–4886. doi: 10.1038/onc.2011.195

Figure 6.

Figure 6

Treatment with Shh N-terminal peptide induces chemotolerance in DLBCL cells. (a) Treatment with Shh N-terminal peptide (250ng/mL) for 24h significantly increases mRNA levels of GLI1, BCL2 and ABCG2 in BJAB and DOHH2 cell lines indicating activation of Hh signaling. (b) Treatment with Shh N-terminal peptide increases chemotolerance of BJAB and DOHH2 cell lines to both doxorubicin and methotrexate (in particular to low-doses of these agents) in comparison with doxorubicin and methotrexate alone. *(p < 0.05).