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Gli3R localizes to the nucleus and induces DNA damage in three human colon carcinoma cell lines. HT29, SW480 and HCT116 cells were transiently transfected with Gli3R for 24 hr and examined by confocal microscopy. Empty vector transfected (Control), or GLI3R transfected (Gli3R) cells were fixed, permeabilized, and stained for nuclei (DAPI), myc expression (myc-tagged Gli3R) or γH2AX (DNA damage).
