Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Cancer Res. 2011 Jul 11;71(17):5904–5914. doi: 10.1158/0008-5472.CAN-10-4173

Figure 7.

Figure 7

Schematic representation of the mechanisms underlying inhibition of HH/Gli signaling that result in cell death. Targeting Smo by cyclopamine is upstream and less effective than targeting Gli1/Gli2 by either GANT61 or Gli3R in eliciting cytotoxicity in human colon carcinoma cells. Blocking Gli1/Gli2 function with GANT61 or Gli3R induces DNA damage marked by formation of γH2AX foci at DNA break sites. An ATM/Chk2 axis is involved in DNA damage signaling downstream of inhibiting Gli1/Gli2 activity. P represents phosphorylation and DSB is double strand break.