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PDX-1 expression in BETA2 −/− pancreas. (A) At E16.0, PDX-1 was expressed throughout the pancreatic epithelium (original magnification, 250×); (B) coimmunolocalization of insulin (imunofluorescence, red, cytoplasmic) and PDX-1 (imunoperoxidase staining, brownish, nuclear) in −/− E16.0 pancreas (original magnification, 1000×). Most insulin-producing cells also coexpressed PDX-1.
