Skip to main content
. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Oncogene. 2011 May 30;30(50):4990–4998. doi: 10.1038/onc.2011.205

Figure 1. Ron expression in wild-type and TRAMP mouse prostates.

Figure 1

A, Prostates from 30-week-old wild-type (TK+/+) or TK−/− mice are histologically similar. Representative sections of the anterior prostates of TK+/+ and TK−/− mice are shown. B, Ron is highly expressed in 30-week-old TK+/+ TRAMP+ prostates compared to TK+/+ prostate tissue. No Ron expression is detected in TK−/− TRAMP+ prostates. Representative tissue sections were stained with a Ron-specific antibody or with an isotype control IgG. TK+/+ prostates have minimal Ron expression whereas TK+/+ TRAMP+ prostate tumors have significantly elevated Ron expression. C, Quantitative real time PCR analysis demonstrates increased Ron mRNA levels in TK+/+ TRAMP+ prostate tumors (n=5) relative to TK+/+ prostates (n=6). Data are expressed as means ± SE. No detectable Ron mRNA expression was observed in the prostates of TK−/− or TK−/− TRAMP+ mice. D, Top: Western analysis of Ron protein levels in a TK+/+ prostate and in a prostate tumor from a TK+/+ TRAMP+ mouse. Bottom: Densitometry analysis of relative Ron protein levels in TK+/+ (n=4) and TK+/+ TRAMP+ (n=5) prostates. Data are expressed as means ± SE. *p<0.05 compared to TK+/+ group.