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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Oncogene. 2011 May 30;30(50):4990–4998. doi: 10.1038/onc.2011.205

Figure 2. TRAMP mice deficient in functional Ron have decreased genitourinary complex and prostate tumor size.

Figure 2

A, 30-week-old TK−/− TRAMP+ mice (n=12) exhibit decreased genitourinary (GU) complex and prostate tumor mass relative to TK+/+ TRAMP+ mice (n=16). Data are expressed as means ± SE. B, Gross examination of genitourinary complexes from TK+/+ TRAMP+ mice and TK−/− TRAMP+ mice demonstrates decreased GU complex size in the TK−/− TRAMP+ mice. C, Representative histological analysis of TK+/+ TRAMP+ and TK−/− TRAMP+ prostates. The asterisk depicts the large tumor bearing area of the TK+/+ TRAMP+ prostate while the arrow indicates one of the several neoplastic regions of TK−/− TRAMP+ prostate. D, Representative image of a lung section containing metastatic foci (arrows) from a TK+/+ TRAMP+ mouse and a corresponding section from a TK−/− TRAMP+ lung. Lungs and prostates were stained with hematoxylin and eosin.