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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Oncogene. 2011 May 30;30(50):4990–4998. doi: 10.1038/onc.2011.205

Figure 3. Prostate tumors from TK−/− TRAMP+ mice are less vascularized than prostates from TRAMP mice expressing wild-type Ron.

Figure 3

A, TRAMP mice lacking functional Ron (TK−/− TRAMP+) have decreased vascularization as determined by immunohistochemistry with a CD31-specific antibody. B, Mean vessel density per area was determined with n=4 mice for the TK+/+ TRAMP+ group and n=3 mice for the TK−/− TRAMP+ group. Data are expressed as means ± SE. *p<0.05 compared to TK+/+ TRAMP+ group. C&D, Quantitative real-time PCR was performed on RNA isolated from prostate tumors from TK+/+ TRAMP+ and TK−/− TRAMP+ mice. Expression of the angiogenic factors VEGF (C) and CXCL2 (D) are shown. Data are expressed as means ± SE with n=4 prostates per group. *p<0.05 compared to TK+/+ TRAMP+ group.