Figure 5. Ron loss in the TRAMP prostate results in decreased levels of active NF-κB.
A, NF-κB reporter assays performed with prostate cells derived from TK+/+ TRAMP+ and TK−/− TRAMP+ prostates. Decreased NF-κB reporter activity was observed in TK−/− TRAMP+ cells compared to TK+/+ TRAMP+ cells. Relative NF-κB activity for each sample is depicted. Data are expressed as the mean ± SE. B, Nuclear extracts from 30-week-old TK+/+ TRAMP+ and TK−/− TRAMP+ prostates were isolated and examined by Western analysis. TK−/− TRAMP+ prostates exhibit decreased levels of nuclear NF-κB p65 relative to TK+/+ TRAMP+ prostates. PARP is shown as a nuclear loading control.