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. 1997 Sep 15;11(18):2438–2447. doi: 10.1101/gad.11.18.2438

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Copyright © 1997, Cold Spring Harbor Laboratory Press

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Resolution-competent arrangements of 2:2 tetramers between Flp(Y343F) and Flp or Flp(Y343F) and Flp(R191S, H305L) on a Holliday junction. (A) Replacement of two weak arms of the Holliday junction by Flp can give three possible arrangements I–III. Whereas I can give only right resolution by the tetramer mechanism, II and III should yield unbiased resolution by the trimer mechanism. (B) Only one of the three double replacements that can be obtained with Flp(R191S, H305L), I, can assemble two resolution-competent active sites. Resolution in this case will be at the right end via the tetramer.

Resolution-competent arrangements of 2:2 tetramers between Flp(Y343F) and Flp or Flp(Y343F) and Flp(R191S, H305L) on a Holliday junction. (A) Replacement of two weak arms of the Holliday junction by Flp can give three possible arrangements I–III. Whereas I can give only right resolution by the tetramer mechanism, II and III should yield unbiased resolution by the trimer mechanism. (B) Only one of the three double replacements that can be obtained with Flp(R191S, H305L), I, can assemble two resolution-competent active sites. Resolution in this case will be at the right end via the tetramer.