Fig. 2.

Proliferative response of T cells activated in presence of different costimulatory signals. Stimulator cells expressing high levels of membrane-bound anti-CD3 in conjunction with CD80, CD58, 4-1BBL, ICOS-L, CD54 or no human costimulatory molecules were co-cultured with human T cells. ³[H]-thymidine uptake was assessed following 3 days of co-culture (cpm, counts per minute). Circles indicate outliers. Box plots show the results of 10 independent experiments with T cells from different healthy donors.