Table 1.

IL-1 cytokine family in inflammatory bowel disease.

Common name	IL-1 family name	Function	Ligand-binding chain	Disease association
IL-1α	IL-1F1	Agonist	IL-1R type I	CD1,2, UC1,2
IL-1β	IL-1F2	Agonist	IL-1R type I	CD1,2, UC1,2
IL-1Ra	IL-1F3	Antagonist	IL-1R type I	UC3,4,5
IL-18	IL-1F4	Agonist	IL-18Rα	CD6,7
	IL-1F5	Agonist	IL-1Rrp2	Unknown
	IL-1F6	Agonist	IL-1Rrp2	Unknown
	IL-1F7	Antagonist	IL-18Rα	Unknown
	IL-1F8	Agonist	IL-1Rrp2	Unknown
	IL-1F9	Agonist	IL-1Rrp2	Unknown
	IL-1F10	Unknown	Unknown	Unknown
IL-33	IL-1F11	Agonist	ST2	UC8,9,10,11

CD, Crohn’s disease; UC, ulcerative colitis.

¹Cominelli [1990].

²Andus [1997].

³Nishiyama [1994].

⁴Ferrettiet al. [1994].

⁵Casini-Raggi et al. [1995].

⁶Pizarro et al. [1999].

⁷Monteleone et al. [1999].

⁸Pastorelli et al. [2010].

⁹Beltran et al. [2010].

¹⁰Kobori et al. [2010].

¹¹Seidelin et al. [2010].