Table 3.
Frequencies of HLA-B and HLA-DRB1 were determined for DOBV-infected patients with different disease progressions and compared among groups
Allele | Frequency (%) among individuals in indicated group |
P value (relative risk)a |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Control (n = 131) | Outcome | Fatal/severe | Fatal/mild | Severe/mild | Fatal/control | Severe/control | Mild/control | |||
Fatal (n = 7) | Severe (n = 31) | Mild (n = 29) | ||||||||
B*07 | 24.4 | 14.3 | 29.0 | 10.3 | NS | NS | NS | NS | NS | NS |
B*08 | 13.7 | 12.9 | 13.8 | NS | NS | NS | NS | NS | NS | |
B*13 | 6.9 | 14.3 | 10.3 | NS | NS | NS | NS | NS | NS | |
B*14 | 3.1 | 6.5 | 10.3 | NS | NS | NS | NS | NS | NS | |
B*15 | 7.6 | 14.3 | 6.5 | 3.5 | NS | NS | NS | NS | NS | NS |
B*18 | 16.0 | 14.3 | 9.7 | 6.9 | NS | NS | NS | NS | NS | NS |
B*27 | 13.0 | 14.3 | 25.8 | 13.8 | NS | NS | NS | NS | 0.096* (1.906) | NS |
B*35 | 23.7 | 57.1 | 32.3 | 31.0 | NS | NS | NS | 0.069* (3.924) | NS | NS |
B*38 | 8.4 | 9.7 | 6.9 | NS | NS | NS | NS | NS | NS | |
B*39 | 3.1 | 3.2 | 6.9 | NS | NS | NS | NS | NS | NS | |
B*40 | 9.9 | 6.5 | 6.9 | NS | NS | NS | NS | NS | NS | |
B*41 | 1.5 | 3.5 | NS | NS | NS | NS | NS | NS | ||
B*44 | 17.6 | 29.0 | 24.1 | NS | NS | NS | NS | NS | NS | |
B*47 | 0.0 | 3.5 | NS | NS | NS | NS | NS | NS | ||
B*49 | 4.6 | 3.2 | 3.5 | NS | NS | NS | NS | NS | NS | |
B*50 | 3.1 | 3.2 | 6.9 | NS | NS | NS | NS | NS | NS | |
B*51 | 13.0 | 12.9 | 24.1 | NS | NS | NS | NS | NS | NS | |
B*55 | 4.6 | 14.3 | 3.2 | 3.5 | NS | NS | NS | NS | NS | NS |
B*57 | 6.9 | 28.6 | 3.2 | 3.5 | 0.081* (4.667) | 0.090* (4.340) | NS | 0.098* (4.618) | NS | NS |
DRB1*01 | 28.2 | 42.9 | 34.4 | 31.3 | NS | NS | NS | NS | NS | NS |
DRB1*03 | 23.7 | 18.8 | 18.8 | NS | NS | NS | NS | NS | NS | |
DRB1*04 | 16.0 | 18.8 | 21.9 | NS | NS | NS | NS | NS | NS | |
DRB1*07 | 18.3 | 28.6 | 21.9 | 21.9 | NS | NS | NS | NS | NS | NS |
DRB1*08 | 3.1 | 3.1 | 9.4 | NS | NS | NS | NS | NS | NS | |
DRB1*11 | 26.0 | 42.9 | 25.0 | 18.8 | NS | NS | NS | NS | NS | NS |
DRB1*12 | 0.8 | 3.1 | 6.3 | NS | NS | NS | NS | NS | NS | |
DRB1*13 | 20.6 | 18.8 | 21.9 | NS | NS | NS | NS | NS | NS | |
DRB1*14 | 8.4 | 14.3 | 9.4 | 15.6 | NS | NS | NS | NS | NS | NS |
DRB1*15 | 22.1 | 14.3 | 18.8 | 15.6 | NS | NS | NS | NS | NS | NS |
DRB1*16 | 16.0 | 14.3 | 9.4 | 9.4 | NS | NS | NS | NS | NS | NS |
P values between control group and/or groups with indicated outcomes were determined using the two-tailed Fischer's exact test. NS, not significant; *, borderline significant (P < 0.1).