Table 3.
Plasma pharmacokinetics of finafloxacin in six healthy volunteers per dose after multiple-dose administration (part B)a
| Dose (mg) | Day no. | Cmax (mg/liter) | Cmax,norm [(mg/liter)/mg] | AUC24h (h · mg/liter) | AUC24h,norm [(h · mg/liter)/mg] | tmax (h) | t1/2 (h) | CL/F (liters/h) | Vz/F (liters) |
|---|---|---|---|---|---|---|---|---|---|
| 150 | 1 | 1.69 ± 0.38 | 0.011 | 3.76 ± 0.82 | 0.025 | 0.50 | |||
| 150 | 7 | 1.50 ± 0.52 | 0.010 | 4.01 ± 0.64 | 0.027 | 0.50 | 5.3 ± 0.6 | 37.4 ± 5.8 | 282 ± 25 |
| 300 | 1 | 2.96 ± 0.88 | 0.0099 | 8.75 ± 3.50 | 0.029 | 1.50 | |||
| 300 | 7 | 4.15 ± 2.11 | 0.014 | 9.09 ± 3.83 | 0.030 | 0.63 | 6.5 ± 2.5 | 37.4 ± 17.5 | 337 ± 155 |
| 600 | 1 | 7.67 ± 3.42 | 0.013 | 18.7 ± 7.63 | 0.031 | 0.75 | |||
| 600 | 7 | 6.76 ± 2.20 | 0.011 | 19.2 ± 6.40 | 0.032 | 0.88 | 8.8 ± 3.1 | 32.5 ± 10.2 | 409 ± 175 |
| 800 | 1 | 8.68 ± 1.96 | 0.011 | 20.8 ± 7.42 | 0.026 | 0.75 | |||
| 800 | 7 | 8.95 ± 3.11 | 0.011 | 26.1 ± 8.60 | 0.033 | 0.88 | 14.0 ± 5.5 | 31.6 ± 10.6 | 659 ± 467 |
a
Where indicated, values are means ± standard deviations. AUC24h, area under the plasma concentration-time curve to 24 h after dosing. For the explanation of other symbols, see the footnote to Table 2.