Fig. 1.

(a and b) Baseline PSMα1 to -4 production in clinical isolates and reference strains. (a) Clinical isolates that caused cSSSIs (n = 50). Horizontal lines represent median values for each PSMα peptide. The interquartile ranges (IQRs) for PSMα1 to -4 were 16.6 to 35.3, 7.8 to 19.4, 8.5 to 17.5, and 17.5 to 44.6 μg/ml, respectively. (b) Staphylococcus aureus control strains. Baseline PSM production of CA, hospital-associated (HA), and laboratory strains of S. aureus was measured after 24 h of incubation at 37 °C and shaking at 200 rpm. Laboratory strain NRS155 is the isogenic agr knockout of NRS149, and NRS144 has a partial agr defect.